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Effects of water-soluble low-molecular-weight beta-1, 3-D-glucan (branch beta-1, 6) isolated from Aureobasidium pullulans 1A1 strain black yeast on restraint stress in mice.
Kimura, Yoshiyuki; Sumiyoshi, Maho; Suzuki, Takahiro; Suzuki, Toshio; Sakanaka, Masahiro.
Afiliação
  • Kimura Y; Division of Biochemical Pharmacology, Department of Basic Medical Research, Graduate School of Medicine, Ehime University, Shitsukawa, Toon City, Ehime 791-0295, Japan. yokim@m.ehime-u.ac.jp
J Pharm Pharmacol ; 59(8): 1137-44, 2007 Aug.
Article em En | MEDLINE | ID: mdl-17725857
ABSTRACT
It is well known that different stress paradigms are able to rapidly induce corticosterone production and immune function through the activation of the hypothalamic-pituitary-adrenal axis. It has been reported that glucocorticoids suppress natural killer (NK) activity and interleukin (IL)-1 production and, on the other hand, that IL-1 and IL-6 stimulate the release of corticotrophin-releasing-hormone from the rat hypothalamus. Moreover, it has been reported that IL-12 plays a central role in the initiation of cell-mediated immunity, directly and via its induction of interferon (IFN)-gamma and activation of NK cells. In this study, we examined the effects of water-soluble low-molecular-weight beta-glucan isolated from Aureobasidium pullulans 1A1 strain on the corticosterone levels and immune function, such as NK activity and IL-6 and IL-12 production, using a restraint stress-induced mouse model. The water-soluble low-molecular-weight beta-glucan at a dose of 50 or 100 mg kg(-1) inhibited the increases in the blood corticosterone level and the reduction of NK activity induced by restraint stress. Furthermore, the water-soluble low-molecular-weight beta-glucan (100 mg kg(-1)) prevented the reduction of IL-6 and IL-12 production by splenocytes caused by restraint stress. These findings suggest that the inhibitory actions of water-soluble low-molecular-weight beta-glucan on the increase in corticosterone level and reduction of NK activity induced by restraint stress may be associated with the abrogation of the IL-6 and IL-12 reduction caused by the stress. Thus, water-soluble low-molecularweight beta-glucan may be an effective dietary supplement for the prevention of stress.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ascomicetos / Estresse Psicológico / Glucanos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Pharm Pharmacol Ano de publicação: 2007 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ascomicetos / Estresse Psicológico / Glucanos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Pharm Pharmacol Ano de publicação: 2007 Tipo de documento: Article