Effect of cardiac resynchronisation therapy on occurrence of ventricular arrhythmia in patients with implantable cardioverter defibrillators undergoing upgrade to cardiac resynchronisation therapy devices.
Heart
; 94(2): 186-90, 2008 Feb.
Article
em En
| MEDLINE
| ID: mdl-17761506
ABSTRACT
BACKGROUND:
Cardiac resynchronisation therapy (CRT) improves outcomes in selected patients with heart failure and left ventricular dysfunction. One mechanism of benefit is believed to be favourable ventricular remodelling. Whether CRT also decreases the frequency of ventricular arrhythmias and risk of sudden death is unknown.OBJECTIVE:
To determine the effect of CRT on frequency of ventricular arrhythmias and appropriate ICD therapies.DESIGN:
Retrospective cohort study.SETTING:
Single-centre, tertiary care facility (Mayo Clinic). PATIENTS 52 patients (46 male), aged 70 (SD 10) years, who underwent upgrade from an implantable cardioverter defibrillator (ICD) to a CRT-defibrillator were included.INTERVENTIONS:
Upgrade of ICD to CRT-defibrillator. MAIN OUTCOMEMEASURES:
Frequency of ventricular arrhythmias prior to and following upgrade to CRT device.RESULTS:
Ejection fraction increased from 22% (SD 8%) to 27% (SD 11%) following CRT. However, the frequency of non-sustained ventricular arrhythmias, sustained ventricular arrhythmias, and ventricular fibrillation was not significantly changed prior to and following CRT (2.38 (SD 9.78) vs 58.51 (SD 412.73) per patient per month, p = 0.66; 0.07 (SD 0.17) vs 0.16 (SD 0.52), p = 0.70; 0.05 (SD 0.12) vs 0.25 (SD 1.40), p = 0.12).CONCLUSIONS:
CRT is not associated with a decrease in the frequency of ventricular arrhythmia or appropriate device therapy. Thus, use of CRT alone is not beneficial in decreasing the frequency of ventricular arrhythmias or the risk of appropriate ICD therapies.
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Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
/
6_ODS3_enfermedades_notrasmisibles
Base de dados:
MEDLINE
Assunto principal:
Marca-Passo Artificial
/
Arritmias Cardíacas
/
Coração Auxiliar
/
Desfibriladores Implantáveis
/
Insuficiência Cardíaca
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Heart
Ano de publicação:
2008
Tipo de documento:
Article