Renal handling of hydrogen ion excretion in relation to maturity indices in premature infants fed human milk.
Child Nephrol Urol
; 11(4): 193-5, 1991.
Article
em En
| MEDLINE
| ID: mdl-1777899
ABSTRACT
In 40 premature infants fed human milk with an actual gestational age of 261 +/- 16 days and an actual body weight of 1.06-2.75 kg, 44 urine samples were collected, and blood acid-base status was measured on day 32 (+/- 16) of life. In the urine, the following results (mean +/- SD) were obtained urine pH 6.05 +/- 0.65, titratable acidity 0.24 +/- 0.14 mmol/kg/day, ammonium 0.78 +/- 0.25 mmol/kg/day, net acid excretion 0.83 +/- 0.47 mmol/kg/day. There was no significant correlation between renal net acid or ammonium excretion and actual body weight. However, urine pH was positively correlated with body weight. Obviously, premature infants with an actual body weight below 1.5 kg need a higher stimulation of renal hydrogen ion secretion to excrete the same amount of ammonium than those with an actual body weight of about 2.5 kg. The limited renal acidification capacity of very low birth weight infants is a risk factor for the development of late metabolic acidosis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Equilíbrio Ácido-Base
/
Recém-Nascido Prematuro
/
Rim
/
Leite Humano
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
/
Newborn
Idioma:
En
Revista:
Child Nephrol Urol
Ano de publicação:
1991
Tipo de documento:
Article