A new animal model for Ménière's disease.
Acta Otolaryngol
; 128(3): 263-71, 2008 Mar.
Article
em En
| MEDLINE
| ID: mdl-17851960
ABSTRACT
CONCLUSION:
A new murine model for the study of Ménière's disease has been developed by treatment with both lipopolysaccharide (LPS) and aldosterone. Induction of vestibular dysfunction in the hydropic animal model may entail additional stress such as reduced inner ear blood flow, and sudden acute changes in endolymph volume and/or pressure.OBJECTIVE:
The purpose of this study was to develop a more suitable animal model, showing closer resemblance to the pathophysiological process in Ménière's disease. MATERIALS ANDMETHODS:
Adult CBA/J mice were treated by intratympanic injection of LPS, intraperitoneal injection of aldosterone, or injection of both LPS and aldosterone. Morphological analyses were performed in the cochlea and endolymphatic sac.RESULTS:
All experimental animals showed mild to moderate endolymphatic hydrops. Those treated with both LPS and aldosterone showed reversible vestibular dysfunction after the intratympanic injection of epinephrine.
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Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Lipopolissacarídeos
/
Hidropisia Endolinfática
/
Modelos Animais de Doenças
/
Aldosterona
/
Escherichia coli
/
Doença de Meniere
Limite:
Animals
Idioma:
En
Revista:
Acta Otolaryngol
Ano de publicação:
2008
Tipo de documento:
Article