High affinity interleukin-6 binding sites in bovine hypothalamus.
Eur J Pharmacol
; 202(1): 113-5, 1991 Sep 04.
Article
em En
| MEDLINE
| ID: mdl-1786797
ABSTRACT
The cytokine interleukin-6 (IL-6) has been proposed to interact with the hypothalamic-pituitary axis. The present data provide the first reported evidence of high affinity binding sites for [125I]IL-6 in brain tissue, specifically bovine hypothalamic membranes. Binding was saturable and represented a single site, with a Kd of 316 +/- 49 pM and receptor density of 15.8 +/- 3.2 fmol/mg protein. Other cytokines tested did not interact with this site, but a neutralizing monoclonal anti-IL-6 antibody blocked specific binding. These findings support the proposed involvement of IL-6 in communication between neural and immune systems.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores Imunológicos
/
Interleucina-6
/
Hipotálamo
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
1991
Tipo de documento:
Article