An erythrodermic variant of pemphigus foliaceus with puzzling histologic and immunopathologic features.
J Cutan Med Surg
; 11(5): 179-84, 2007.
Article
em En
| MEDLINE
| ID: mdl-17942028
ABSTRACT
BACKGROUND:
Pemphigus foliaceus is an autoimmune blistering disorder that affects the skin owing to autoantibodies against desmoglein 1.METHODS:
We employed clinical, histologic, immunopathologic, and serum laboratory studies to investigate a case of an erythrodermic variant of pemphigus foliaceus in an elderly man following treatment with bisoprolol-hydrochlorothiazide.RESULTS:
Early histopathology revealed psoriasiform dermatitis, but later biopsies showed subcorneal and granular layer separation with neutrophilic infiltrate. Direct immunofluorescence showed intercellular deposits of immunoglobulin G throughout the epidermis, granular staining of C3 along the basement membrane zone, and fibrin and C3 deposition around the blood vessels. Indirect immunofluorescence on monkey esophagus showed a titer of greater than 11,280. Indirect immunofluorescence on rat bladder, antinuclear antibody, lupus panel, and kidney function panel were all negative.CONCLUSION:
There are no reports in the literature of pemphigus foliaceus being induced by bisoprolol, but reports exist of propanolol resulting in drug-induced pemphigus foliaceus.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Pênfigo
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
Limite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
J Cutan Med Surg
Ano de publicação:
2007
Tipo de documento:
Article