[Effect of semiconductor quantum dots on cyto-biological behavior of tongue squamous cell carcinoma cell line Tca8113].

ABSTRACT

OBJECTIVE: To study the effect of semiconductor quantum dots (QD), a kind of new luminescent inorganic non-crystals on biological behavior of tongue squamous cell carcinoma cell line Tca8113. METHODS: Different concentrations of QD were cocultured with Tca8113 cells, and the status of cancer cell growth in three experimental groups and control was compared respectively. Tca8113 cells were labeled by QD (Tca8113-QD), and then transwell chambers and washing away method were used to detect the difference of invasion and metastatic ability between Tca8113-QD and Tca8113 cells. RESULTS: The different concentrations of QD showed no negative effects on growth of Tca8113 cells. The ability of invasion, attachment and chemotaxis movement of Tca8113 cells were not significantly different between the experimental groups and control. CONCLUSIONS: QD showed no effects on growth, invasion and metastatic ability of Tca8113 cells and may serve as a new fluorescence probe in living tumor cell study.