Pharmacokinetics of intraperitoneally instilled aminophylline, terbutaline and tobramycin in pigs.
Acta Anaesthesiol Scand
; 52(2): 243-8, 2008 Feb.
Article
em En
| MEDLINE
| ID: mdl-18005375
ABSTRACT
INTRODUCTION:
Venous catheters are sometimes difficult or even impossible to insert and may also be associated with serious complications. This study was carried out to investigate whether intraperitoneal administration of drugs may be an alternative to the intravenous route in patients with limited vascular access. MATERIALS ANDMETHODS:
Three drugs commonly in use in clinical practise, aminophylline, terbutaline and tobramycin, were administered to pigs intravenously and intraperitoneally in small volumes. Serum concentrations were analysed over a period of 6 h and pharmacokinetic key variables for each drug were calculated.RESULTS:
Aminophylline (theophylline), terbutaline and tobramycin were absorbed from the peritoneal space and into systemic circulation. For theophylline, the concentration/time profiles after intraperitoneal and after intravenous administration were almost identical, and the intraperitoneal bioavailability was calculated to 0.94. For terbutaline and tobramycin, the intraperitoneal absorption was delayed without any initial peak. Moreover, the intraperitoneal bioavailability was lower than for theophylline (0.71 and 0.65, respectively).CONCLUSION:
The pharmacokinetic properties after intraperitoneal administration differed among the three drugs, but the results are encouraging and provide a basis for further investigation in humans.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Terbutalina
/
Tobramicina
/
Broncodilatadores
/
Aminofilina
/
Antibacterianos
Limite:
Animals
Idioma:
En
Revista:
Acta Anaesthesiol Scand
Ano de publicação:
2008
Tipo de documento:
Article