Mineralocorticoid receptor is essential for corticosteroid-induced up-regulation of L-type calcium currents in cultured neonatal cardiomyocytes.
Pflugers Arch
; 456(2): 407-12, 2008 May.
Article
em En
| MEDLINE
| ID: mdl-18040710
ABSTRACT
Despite the fact that mineralocorticoid receptor (MR) antagonist drugs such as spironolactone and eplerenone reduce the mortality in heart failure patients, there is, thus far, no unambiguous demonstration of a functional role of MR in cardiac cells. The aim of this work was to investigate the activation pathway(s) mediating corticosteroid-induced up-regulation of cardiac calcium current (ICa). In this study, using neonatal cardiomyocytes from MR or glucocorticoid receptor (GR) knockout (KO) mice, we show that MR is essential for corticosteroid-induced up-regulation of ICa. This study provides the first direct and unequivocal evidence for MR function in the heart.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Corticosteroides
/
Receptores de Mineralocorticoides
/
Canais de Cálcio Tipo L
/
Miócitos Cardíacos
Limite:
Animals
Idioma:
En
Revista:
Pflugers Arch
Ano de publicação:
2008
Tipo de documento:
Article