New polyphenols active on beta-amyloid aggregation.
Bioorg Med Chem Lett
; 18(2): 828-31, 2008 Jan 15.
Article
em En
| MEDLINE
| ID: mdl-18042380
ABSTRACT
New polyphenol classes have been tested against amyloid-beta peptide aggregation. We have identified four novel polyphenols which could be efficient fibril inhibitors in Alzheimer's disease malvidin and its glucoside and curculigosides B and D. We suggest that molecules with the particular C(6)-linkers-C(6) structure could be potent inhibitors. From the results reported for the flavan-3-ol family, their anti-amyloidogenic effects against whole peptides (1-40 and 1-42) could involve several binding sites.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenóis
/
Flavonoides
/
Peptídeos beta-Amiloides
Limite:
Aged
/
Aged80
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Ano de publicação:
2008
Tipo de documento:
Article