Immunohistochemical and ultrastructural features of Langerhans cells in condyloma acuminatum.
J Cutan Pathol
; 35(1): 15-20, 2008 Jan.
Article
em En
| MEDLINE
| ID: mdl-18095989
ABSTRACT
BACKGROUND:
There are few studies on the abnormal morphology of Langerhans cells (LCs) in condyloma acuminatum (CA) lesions and the essence of the abnormal morphology of LCs in CA lesions is still not well elucidated. The aim of this study was to further investigate the morphological features of LCs in CA lesions.METHODS:
CD1a(+) LCs in 13 CA lesions and in 13 normal controls were labeled using immunohistochemistry and examined by light microscopy. Ultrastructural investigation on LCs in six CA lesions and in six normal controls was performed by electron microscopy.RESULTS:
Compared with those in normal controls, most CD1a(+) LCs in CA lesions exhibited dysplastic dendrities and abnormal distribution. The number of CD1a(+) LCs in CA lesions (26.31 +/- 18.84) was statistically lower (p < 0.001) than that in normal controls (72.00 +/- 27.40). Electron microscopy showed that the number of Birbeck granules within lesional LCs (4.00 +/- 2.94) was significantly decreased (p < 0.001) than that within normal LCs (10.80 +/- 4.78). The ultrastructures of most lesional LCs displayed degenerative changes.CONCLUSIONS:
The morphology of most LCs in CA lesions shows degenerative changes, which suggest that these LCs have been functionally impaired.
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Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Doenças do Pênis
/
Condiloma Acuminado
/
Células de Langerhans
/
Prepúcio do Pênis
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
J Cutan Pathol
Ano de publicação:
2008
Tipo de documento:
Article