Addition of N-carbobenzyloxy-L-tryptophan as a co-template molecule to molecularly imprinted polymer monoliths for (+)-nilvadipine.
J Chromatogr A
; 1185(2): 258-62, 2008 Mar 28.
Article
em En
| MEDLINE
| ID: mdl-18262193
ABSTRACT
Molecularly imprinted polymer (MIP) monoliths for (+)-nilvadipine have been prepared using 4-vinylpyridine as a functional monomer and toluene/1-dodecanol as a porogen without or with addition of N-carbobenzyloxy-L-tryptophan (Cbz-L-Trp) as a co-template molecule. The MIP monoliths prepared with (+)-nilvadipine as a sole template molecule had no macro through-pores, while those could be formed by addition of Cbz-L-Trp as the co-template molecule. Furthermore, on the former nilvadipine enantiomers could not be separated, but on the latter they could. The presence of Cbz-L-Trp affected the polymerization process and resulted in forming macro through-pores of the MIP monoliths for (+)-nilvadipine and attaining separation of nilvadipine enantiomers. These results suggest that co-addition of Cbz-L-Trp could be effective for preparing MIP monoliths for (+)-nilvadipine, whose preparation is difficult.
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Base de dados:
MEDLINE
Assunto principal:
Triptofano
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Microscopia Eletrônica de Varredura
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Nifedipino
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Cromatografia de Afinidade
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Impressão Molecular
Idioma:
En
Revista:
J Chromatogr A
Ano de publicação:
2008
Tipo de documento:
Article