Uterine myometrium as a cell patch as an alternative graft for transplantation to infarcted cardiac myocardium: a preliminary study.
Int J Artif Organs
; 31(1): 62-7, 2008 Jan.
Article
em En
| MEDLINE
| ID: mdl-18286456
ABSTRACT
PURPOSE:
Currently, only a small fraction of patients are able to receive reperfusion therapy for myocardial infarctions. We hypothesize that myometrial cell patch transplantation could be an alternative approach for the treatment of myocardial infarction.DESIGN:
We performed a preliminary study to determine the feasibility of this novel therapeutic approach in a rabbit model. PROCEDURES Six adult female New Zealand rabbits were used. Myocardial infarction was induced by left anterior descending artery ligation. A segment of uterus was removed via a laparotomy incision, and this uterine segment was transplanted as an autologous graft over the infarcted myocardium, which was then reinforced by greater omentum. Statistical methods and outcomemeasures:
Hemodynamic measurements and histological studies. MAINFINDINGS:
All uterine myometrial patches survived in the test animals. Fluoroscopic hemodynamic measurements were made for ejection fractions at 8 weeks after the application of the uterine patch. Histological study demonstrated well-healed myometrial-myocardium junctions with minimum scar tissue. Angiogenesis occurred in the transplanted myometrium. Connexin 43 expression was demonstrated in the transplanted patches.CONCLUSION:
Our noncontrolled preliminary rabbit experiments indicate that patches of uterine myometrium reinforced by greater omentum can be used as autologous transplant therapy for infracted myocardium. This is an innovative technique that could lead to future treatment for individuals who may suffer from an infarcted myocardium and may not be eligible for traditional reperfusion therapy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cardiomioplastia
/
Transplantes
/
Transplante de Células-Tronco
/
Infarto do Miocárdio
/
Miométrio
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Int J Artif Organs
Ano de publicação:
2008
Tipo de documento:
Article