Light damaging action of all-trans-retinal and its derivatives on rhodopsin molecules in the photoreceptor membrane.
Biochemistry (Mosc)
; 73(2): 130-8, 2008 Feb.
Article
em En
| MEDLINE
| ID: mdl-18298368
ABSTRACT
We have reproduced the model system containing A2-rhodopsin, NR-PE, A2-PE, and ATR-dimer-PE in order to study photosensitized damage of rhodopsin within photoreceptor membranes of rod outer segments. We have demonstrated that irradiation of such a system with visible light (400-700 nm) distorts the most important functional property of native visual pigment--its ability to regenerate after addition of 11-cis-retinal in the dark. We have also shown that all-trans-retinal bound to membrane phospholipids and rhodopsin has less photosensitizing activity that free all-trans-retinal.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Retinaldeído
/
Rodopsina
/
Segmento Externo da Célula Bastonete
Idioma:
En
Revista:
Biochemistry (Mosc)
Ano de publicação:
2008
Tipo de documento:
Article