Cytological Ki-67 in pancreatic endocrine tumours: an opportunity for pre-operative grading.
Endocr Relat Cancer
; 15(1): 175-81, 2008 Mar.
Article
em En
| MEDLINE
| ID: mdl-18310285
ABSTRACT
The cytological Ki-67 expression measured on cytological samples collected by endoscopic ultrasonography-guided fine needle aspiration cytology (EUS-FNAC) may provide pre-operative indications for pancreatic endocrine tumours (PETs) management. The aim of our study was to assess reliability of Ki-67 expression measured on cytological samples obtained by EUS-FNAC in patients with PETs. Eighteen patients with PETs underwent EUS-FNAC before surgery. Ki-67 expression was measured on FNACs and on histological sections. Using a cut-off of 2%, percent agreement of Ki-67 expression on cytological and histological samples was 89% (k-statistic 0.78, 95% confidence intervals (95% CI) 0.5, 1.0). Using cut-off values of 2 and 10%, percent agreement was 78% (k-statistic 0.65, 95% CI 0.3, 0.9). Ki-67 expression measured on cytological samples obtained by EUS-FNAC before surgery showed good agreement with that measured on histological samples.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
/
Antígeno Ki-67
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Insulinoma
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Endocr Relat Cancer
Ano de publicação:
2008
Tipo de documento:
Article