Upregulation of PD-L1 on monocytes and dendritic cells by HIV-1 derived TLR ligands.
AIDS
; 22(5): 655-8, 2008 Mar 12.
Article
em En
| MEDLINE
| ID: mdl-18317010
ABSTRACT
Increased PD-L1 expression has been reported in HIV-1-infected individuals, but the mechanisms leading to PD-L1 upregulation remain to be elucidated. Here we demonstrate that HIV-1-derived Toll-like receptor (TLR)7/8 ligands can induce MyD88-dependent upregulation of PD-L1 on plasmacytoid dendritic cells, myeloidic dendritic cells and monocytes. These data suggest a mechanism through which HIV-1-derived TLR ligands might contribute to the functional impairment of virus-specific PD-1-positive T cells by inducing the upregulation of PD-L1 on antigen-presenting cells.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Dendríticas
/
Monócitos
/
Antígenos CD
/
Infecções por HIV
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Regulação para Cima
/
HIV-1
Limite:
Humans
Idioma:
En
Revista:
AIDS
Ano de publicação:
2008
Tipo de documento:
Article