Organocatalytic asymmetric total synthesis of (R)-rolipram and formal synthesis of (3S,4R)-paroxetine.
Org Lett
; 10(7): 1389-91, 2008 Apr 03.
Article
em En
| MEDLINE
| ID: mdl-18324820
ABSTRACT
An efficient enantioselective total synthesis of (R)-rolipram and an efficient enantioselective formal synthesis of (3S,4R)-paroxetine has been achieved using the highly enantioselective Michael addition of malonate nucleophiles as key steps in both cases.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Paroxetina
/
Rolipram
Idioma:
En
Revista:
Org Lett
Ano de publicação:
2008
Tipo de documento:
Article