Withdrawal from high-dose tranylcypromine.
Clin Toxicol (Phila)
; 46(3): 261-3, 2008 Mar.
Article
em En
| MEDLINE
| ID: mdl-18344110
ABSTRACT
A 34-year-old man with a history of multiple substance abuse (now abstinent for six years) became addicted to tranylcypromine, consuming up to 240 mg/day. After discontinuing the drug, he developed thrombocytopenia (52,000/ul) and delirium; there were no other anticholinergic signs. The delirium was unresponsive to haloperidol and diazepam. Intravenous administration of physostigmine (2 mg) on hospital day 6 resulted in prompt, but temporary, clearing of the delirium. Following a recurrence of the delirium after 30 minutes, he was started on an intravenous infusion of physostigmine (2 mg/hr) with good results. Physostigmine administration did not produce any cholinergic signs. By hospital day 8, he did not require any more physostigmine. Thrombocytopenia resolved on hospital day 9 without therapeutic intervention. On hospital day 10, the patient was asymptomatic and left the hospital on his own recognizance.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
/
8_ODS3_consumo_sustancias_psicoactivas
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Abstinência a Substâncias
/
Tranilcipromina
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Inibidores da Monoaminoxidase
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Clin Toxicol (Phila)
Ano de publicação:
2008
Tipo de documento:
Article