[The effects of n-stearoylethanolamine on the NO-synthase pathway of NO generation in the aorta and heart of streptozotocin-induced diabetic rats].
Ukr Biokhim Zh (1999)
; 79(5): 153-8, 2007.
Article
em Uk
| MEDLINE
| ID: mdl-18357789
ABSTRACT
The aim of the presented experiments was to study the influence of suturated NAE--N-stearoylethanolamine (NSE) on the NO synthesis by NO-synthases in aorta and heart tissues of rats with developmental (12-week) streptozotocin-induced (50 mg/kg of body weight) diabetes. Also we evaluated the state of endothelium-dependent relax reactions of aorta smooth muscles. It was shown that the development of diabetes is accompanied with disbalance of NO-synthesis wich consist in inducible NOS (iNOS) activation and inhibition of constitutive NOS (cNOS) and arginase activities. The aorta smooth muscle endothelium-dependent relax reactions were decreased in diabetic rats. The NSE administration to rats with development streptozotocin-induced diabetes resulted in inhibition of iNOS activity and elevation of cNOS and arginase activities in these tissues. Normalization of NO-synthesis under NSE action was accompanied with restoration of aorta smooth muscle endothelium-dependent relax reactions in diabetic rats.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aorta Torácica
/
Ácidos Esteáricos
/
Óxido Nítrico Sintase
/
Diabetes Mellitus Experimental
/
Etanolaminas
/
Miocárdio
/
Óxido Nítrico
Limite:
Animals
Idioma:
Uk
Revista:
Ukr Biokhim Zh (1999)
Ano de publicação:
2007
Tipo de documento:
Article