Evolutionary plasticity of genetic interaction networks.
Nat Genet
; 40(4): 390-1, 2008 Apr.
Article
em En
| MEDLINE
| ID: mdl-18362882
ABSTRACT
Non-additive genetic interactions contribute to many genetic disorders, but they are extremely difficult to predict. Here we show that genetic interactions identified in yeast, unlike gene functions or protein interactions, are not highly conserved in animals. Genetic interactions are therefore unlikely to represent simple redundancy between genes or pathways, and genetic interactions from yeast do not directly predict genetic interactions in higher eukaryotes, including humans.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saccharomyces cerevisiae
/
Caenorhabditis elegans
/
Evolução Molecular
/
Mapeamento de Interação de Proteínas
/
Redes Reguladoras de Genes
/
Genes Letais
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Nat Genet
Ano de publicação:
2008
Tipo de documento:
Article