Inhibitory effects of ginseng total saponin on up-regulation of cAMP pathway induced by repeated administration of morphine.
Arch Pharm Res
; 31(2): 167-70, 2008 Feb.
Article
em En
| MEDLINE
| ID: mdl-18365685
ABSTRACT
We have reported that ginseng total saponin (GTS) inhibited the development of physical and psychological dependence on morphine. However, the possible molecular mechanisms of GTS are unclear. Therefore, this study was undertaken to understand the possible molecular mechanism of GTS on the inhibitory effects of morphine-induced dependence. It has been reported that the up-regulated cAMP pathway in the LC of the mouse brain after repeated administration of morphine contributes to the feature of withdrawals. GTS inhibited up-regulation of cAMP pathway in the LC after repeated administration of morphine in this experiment. GTS inhibited cAMP levels and protein expression of protein kinase A (PKA). In addition, GTS inhibited the increase of cAMP response element binding protein (CREB) phosphorylation. Therefore, we conclude that the inhibitory effects of GTS on morphine-induced dependence might be mediated by the inhibition of cAMP pathway.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saponinas
/
Transdução de Sinais
/
AMP Cíclico
/
Panax
/
Analgésicos Opioides
/
Morfina
Limite:
Animals
Idioma:
En
Revista:
Arch Pharm Res
Ano de publicação:
2008
Tipo de documento:
Article