A mechanism coupling cell division and the control of apoptosis.
SEB Exp Biol Ser
; 59: 257-65, 2008.
Article
em En
| MEDLINE
| ID: mdl-18368928
ABSTRACT
Our recent results demonstrate that caspase activation is regulated during the cell cycle, establishing a direct link between the regulation of apoptosis and cell division (Allan and Clarke, 2007). We show that phosphorylation of caspase-9 is critical for the balance between these processes, restraining the initiation of apoptosis during mitosis. This mechanism is likely to be important in determining sensitivity to anti-cancer drugs that target mitotic cells. We propose that regulation of the phosphorylation of caspase-9 during prolonged mitotic arrest may provide a timing mechanism that initiates apoptosis and destroys an aberrant cell if mitosis is not successfully resolved. This mechanism may play an important role in anti-cancer surveillance and might be exploited to improve cell killing by anti-cancer drugs that target mitotic cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Divisão Celular
/
Apoptose
Limite:
Animals
Idioma:
En
Revista:
SEB Exp Biol Ser
Ano de publicação:
2008
Tipo de documento:
Article