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Leptin, insulin, and glucose serum levels in large-for-gestational-age infants of diabetic and non-diabetic mothers.
Vela-Huerta, M Martha; San Vicente-Santoscoy, Edgar Ulises; Guizar-Mendoza, Juan Manuel; Amador-Licona, Norma; Aldana-Valenzuela, Carlos; Hernnández, Javier.
Afiliação
  • Vela-Huerta MM; Department of Neonatology, Hospital of Gynecology-Pediatrics, Mexican Institute of Social Security, León, México. mmavehu@yahoo.com.mx
J Pediatr Endocrinol Metab ; 21(1): 17-22, 2008 Jan.
Article em En | MEDLINE | ID: mdl-18404969
BACKGROUND: It has been suggested that hyperleptinemia could be caused by hyperinsulinemia in infants of diabetic mothers (IDMs). AIM: To compare leptin, insulin, and glucose levels in large-for-gestational-age (LGA) and appropriate-for-gestational-age (AGA) infants. METHODS: A cross-sectional study was conducted in IDMs, infants of non-diabetic mothers (INDM) and AGA infants. RESULTS: Seventy-seven newborns were studied (11 IDM, 16 INDM, and 50 AGA infants). Leptin levels were significantly higher in LGA infants than in the AGA group and a trend for higher levels in IDM than NIDM was observed. Insulin levels and insulin resistance were significantly higher in IDMs. Glucose levels were lower in both groups of LGA infants. CONCLUSIONS: We found insulin resistance, hyperinsulinism and hyperleptinemia in IDMs, and the trend of higher leptin levels in IDMs than INDMs shows that leptin could be related to insulin resistance in these infants.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicemia / Macrossomia Fetal / Recém-Nascido / Leptina / Diabetes Mellitus / Insulina / Obesidade Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Female / Humans / Male / Pregnancy Idioma: En Revista: J Pediatr Endocrinol Metab Ano de publicação: 2008 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicemia / Macrossomia Fetal / Recém-Nascido / Leptina / Diabetes Mellitus / Insulina / Obesidade Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Female / Humans / Male / Pregnancy Idioma: En Revista: J Pediatr Endocrinol Metab Ano de publicação: 2008 Tipo de documento: Article