Leptin, insulin, and glucose serum levels in large-for-gestational-age infants of diabetic and non-diabetic mothers.
J Pediatr Endocrinol Metab
; 21(1): 17-22, 2008 Jan.
Article
em En
| MEDLINE
| ID: mdl-18404969
BACKGROUND: It has been suggested that hyperleptinemia could be caused by hyperinsulinemia in infants of diabetic mothers (IDMs). AIM: To compare leptin, insulin, and glucose levels in large-for-gestational-age (LGA) and appropriate-for-gestational-age (AGA) infants. METHODS: A cross-sectional study was conducted in IDMs, infants of non-diabetic mothers (INDM) and AGA infants. RESULTS: Seventy-seven newborns were studied (11 IDM, 16 INDM, and 50 AGA infants). Leptin levels were significantly higher in LGA infants than in the AGA group and a trend for higher levels in IDM than NIDM was observed. Insulin levels and insulin resistance were significantly higher in IDMs. Glucose levels were lower in both groups of LGA infants. CONCLUSIONS: We found insulin resistance, hyperinsulinism and hyperleptinemia in IDMs, and the trend of higher leptin levels in IDMs than INDMs shows that leptin could be related to insulin resistance in these infants.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicemia
/
Macrossomia Fetal
/
Recém-Nascido
/
Leptina
/
Diabetes Mellitus
/
Insulina
/
Obesidade
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
/
Pregnancy
Idioma:
En
Revista:
J Pediatr Endocrinol Metab
Ano de publicação:
2008
Tipo de documento:
Article