CNS lymphomatoid granulomatosis with lymph node and bone marrow involvements.
Neuropathology
; 28(6): 640-4, 2008 Dec.
Article
em En
| MEDLINE
| ID: mdl-18410281
ABSTRACT
Lymphomatoid granulomatosis (LYG) in the CNS is an uncommon lymphoproliferative disease with characteristic angiocentric lymphoreticular proliferative and granulomatous lesions exhibiting low-grade malignant potential. Here we report a rare case of CNS-LYG, which disseminated to the lymph node and bone marrow. A 50-year-old man was diagnosed with CNS-LYG based on brain biopsy showing perivascular infiltration of CD3-positive small T-lymphocytes without overt nuclear atypism. Eight months after the initial neurological symptoms, inguinal lymph node swelling was found and histopathologically diagnosed as peripheral T-cell lymphoma. TCRgamma-gene rearrangement study using both paraffin-embedded specimens of brain and inguinal lymph node demonstrated an identical clonal band. Considering the clinical course, we concluded lymph node involvement of CNS-LYG, suggesting the malignant potential of CNS-LYG.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medula Óssea
/
Neoplasias Encefálicas
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Linfonodos
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Granulomatose Linfomatoide
Limite:
Humans
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Male
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Middle aged
Idioma:
En
Revista:
Neuropathology
Ano de publicação:
2008
Tipo de documento:
Article