Skewed X-chromosome inactivation in Greek women with idiopathic recurrent miscarriage.
Fetal Diagn Ther
; 23(3): 198-203, 2008.
Article
em En
| MEDLINE
| ID: mdl-18417978
ABSTRACT
OBJECTIVES:
To investigate if skewed X-chromosome inactivation (XCI) is associated with unexplained recurrent miscarriage (RM) in Greek women.METHODS:
This was a prospective case-control study. A methylation-sensitive assay was used to investigate the X-inactivation pattern of women with unexplained RM and controls.RESULTS:
Fifty-six of the 74 patients (75.7%) and 55 of 80 controls (68.8%) were informative. Among the informative cases, 6/56 (10.7%) women showed extreme XCI (>90%) and among the informative controls, 2/55 (3.6%) showed extreme XCI.CONCLUSIONS:
In the present study, women with unexplained RM showed a statistically nonsignificant increase in skewed XCI prevalence (10.7%) compared with control women (3.6%; p = 0.271).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aborto Habitual
/
Inativação do Cromossomo X
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Pregnancy
País/Região como assunto:
Europa
Idioma:
En
Revista:
Fetal Diagn Ther
Ano de publicação:
2008
Tipo de documento:
Article