The emperors of the schizophrenia polygene have no clothes.
Psychol Med
; 38(12): 1681-5, 2008 Dec.
Article
em En
| MEDLINE
| ID: mdl-18423075
ABSTRACT
A substantial body of research literature, identified by nine out of ten papers on genetics in the recent ISI research front on schizophrenia, claims to have established associations between aspects of the disease and sequence variation in specific candidate genes. These candidatures have proven unreplicated in large sibling pair linkage surveys and a targeted association study. Even if the case for an association be regarded as a lucky guess (assuming one gene in 30 000 was guessed right) the large linkage and association studies provide no evidence of sequence variation relating to psychosis at any of these gene loci. Thus this body of work must be regarded as an indicator of the extent to which the 'eye of faith' is able to discern meaning in complex data when none is present.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Expressão Gênica
/
Herança Multifatorial
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Psychol Med
Ano de publicação:
2008
Tipo de documento:
Article