Antiinflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillus.
Proc Natl Acad Sci U S A
; 105(16): 6150-5, 2008 Apr 22.
Article
em En
| MEDLINE
| ID: mdl-18427110
ABSTRACT
Bacillus anthracis, the etiologic agent of anthrax, avoids immune surveillance and commandeers host macrophages as a vehicle for lymphatic spreading. Here, we show that B. anthracis edema toxin (ET), via its adenylyl cyclase activity, dramatically increases the motility of infected macrophages and the expression of vascular endothelial growth factor. The transcription factor CREB and the syndecan-1 gene, a CREB target, play crucial roles in ET-induced macrophage migration. These molecular and cellular responses occur in macrophages engaged in antiinflammatory G protein-coupled receptor activation, thus illustrating a common signaling circuitry controlling resolution of inflammation and host cell hijacking by B. anthracis.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Bacillus anthracis
/
Movimento Celular
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Regulação da Expressão Gênica
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AMP Cíclico
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Macrófagos
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Antraz
Limite:
Animals
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Ano de publicação:
2008
Tipo de documento:
Article