Efficacy of cefditoren in the treatment of upper respiratory tract infections: a pooled analysis of six clinical trials.
Rev Esp Quimioter
; 21(1): 14-21, 2008 Mar.
Article
em En
| MEDLINE
| ID: mdl-18443928
ABSTRACT
OBJECTIVE:
A pooled analysis of all upper respiratory tract infection studies performed with cefditoren (CDN) was performed.METHODS:
Studies were prospective, comparative, multicentre and randomised. Comparators were penicillin V (pharyngitis) and cefuroxime or amoxicillin/clavulanate (sinusitis). A total of 1,322 patients were randomized, 1,241 included in intention-to-treat (ITT) and 1,010 in per-protocol populations (PP) in pharyngotonsillitis studies, and 1,819 randomized, 1,726 included in ITT and 1,589 in PP in acute sinusitis studies.RESULTS:
No significant differences in pharyngitis clinical response were found (success rates 89.4 % to 95.3 %). S. pyogenes eradication was higher with cefditoren at end of therapy (EOT) (90.4% vs. 82.7%; p=0.002) and follow-up (84.7% vs. 76.7%; p=0.008), although no statistically significant (p<0.001). In both groups, clinical failures were significantly higher (p<0.001) in patients showing S. pyogenes persistence than in those showing eradication (> or =98.5% vs. 51.4 %). No differences in sinusitis clinical response were found between CDN and comparators both at EOT (80.2% vs. 84.8%) and at end of follow-up (71.2% vs. 77.4%).CONCLUSION:
Cefditoren had similar point estimates of clinical efficacy to comparators in pharyngotonsillitis and sinusitis, and a tendency to higher S. pyogenes eradication in pharyngotonsillitis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções Respiratórias
/
Cefalosporinas
/
Antibacterianos
Tipo de estudo:
Clinical_trials
/
Guideline
Limite:
Humans
Idioma:
En
Revista:
Rev Esp Quimioter
Ano de publicação:
2008
Tipo de documento:
Article