CSF monoamine metabolites and neuropeptides in depressed patients before and after electroconvulsive therapy.
Eur Psychiatry
; 23(5): 356-9, 2008 Aug.
Article
em En
| MEDLINE
| ID: mdl-18455913
ABSTRACT
Antidepressant drugs affect monoamines and neuropeptides in human cerebrospinal fluid (CSF) and in rodent brain. The purpose of this study was to investigate if also electroconvulsive therapy (ECT) affects these compounds in a similar manner in the CSF of depressed patients. Homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), and corticotropin-releasing hormone (CRH)-like immunoreactivity (-LI) and neuropeptide Y (NPY)-LI were determined in CSF in six drug resistant patients with major depression. Lumbar puncture was performed at baseline and after completion of eight ECTs. ECT was associated with an increase in NPY-LI (p=0.009) and a decrease in CRH-LI (p
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Neuropeptídeos
/
Hormônio Liberador da Corticotropina
/
Taquicininas
/
Ácido Valproico
/
Transtorno Depressivo Maior
/
Eletroconvulsoterapia
/
Indóis
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Eur Psychiatry
Ano de publicação:
2008
Tipo de documento:
Article