Neuroprotection of ginsenoside Re in cerebral ischemia-reperfusion injury in rats.
J Asian Nat Prod Res
; 10(5-6): 439-45, 2008.
Article
em En
| MEDLINE
| ID: mdl-18464084
ABSTRACT
In the present study, we have investigated the neuroprotective potential of ginsenoside Re (Re) in the middle cerebral artery occlusion model in Sprague-Dawley rats. Adult male Sprague-Dawley rats were treated with Re (5, 10 or 20 mg kg(- 1), P.O. for 7 days, once a day) prior to occlusion. There was a significant increase in the neurological symptoms in ischemic animals as compared with the sham group animals. These effects were attenuated by 10 and 20 mg kg(- 1) Re, P.O. There was a significant increase in the level of malondialdehyde (MDA) in ischemic animals indicating oxidative stress. An elevated level of MDA in ischemic animals was reduced by 10 and 20 mg kg(- 1) Re, P.O., respectively. It was observed that Re significantly decreased mitochondrial swelling, thereby preventing the reduction of H(+)-ATPase activity. This study demonstrates the neuroprotective potential of Re in cerebral ischemia-reperfusion injury in rats.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peroxidação de Lipídeos
/
ATPases Translocadoras de Prótons
/
Fármacos Neuroprotetores
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Ginsenosídeos
/
Dilatação Mitocondrial
Limite:
Animals
Idioma:
En
Revista:
J Asian Nat Prod Res
Ano de publicação:
2008
Tipo de documento:
Article