Distribution and residue depletion of oxytetracycline in giant freshwater prawn (Macrobrachium rosenbergii).
J Food Prot
; 71(4): 870-3, 2008 Apr.
Article
em En
| MEDLINE
| ID: mdl-18468050
ABSTRACT
Distribution and residue depletion patterns of oxytetracycline were examined in giant freshwater prawns, Macrobrachium rosenbergii, after medicated-feed treatment at the feeding level of 4 g/kg of feed for 5 consecutive days. The concentration of oxytetracycline in prawn muscle tissues was measured using high-performance liquid chromatography equipped with a fluorescence detector. The limit of detection was 0.1 microg/g. In the medicated-feed-treated group, oxytetracycline was detectable 8 days posttreatment at the feeding level of 4 g/kg of feed for 5 consecutive days. The depletion half-life and mean residence time of oxytetracycline were 30.96 and 100.3 h, respectively. The dose of 4 g/kg of feed for 5 consecutive days can be recommended for therapeutic dosage regimen in giant freshwater prawn aquaculture. The minimal withdrawal period of M. rosenbergii muscle tissue should be 8 days postcessation of medicated feed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxitetraciclina
/
Frutos do Mar
/
Resíduos de Drogas
/
Contaminação de Alimentos
/
Palaemonidae
/
Antibacterianos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Food Prot
Ano de publicação:
2008
Tipo de documento:
Article