Hyaluronic Acid inhibits polycation induced cellular responses.
Mediators Inflamm
; 3(4): 287-9, 1994.
Article
em En
| MEDLINE
| ID: mdl-18472954
ABSTRACT
Positively charged macromolecules cause a variety of pathological events through their electrostatic interaction with anionic sites present on the membrane of target cells. In the present study we have investigated the effect of hyaluronic acid, a negatively charged molecule, on rat paw oedema induced by poly-L-lysine as well as on histamine release from rat mast cells and nitric oxide formation from rabbit aorta, both induced by this polycation. The results indicate that hyaluronic acid is able to suppress these poly-L-lysine induced effects with a mechanism which possibly depends on its negative charges which may balance the effects of positively charged polycations.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Mediators Inflamm
Ano de publicação:
1994
Tipo de documento:
Article