[Criteria for diagnosis of the neurological stage of human African trypanosomiasis: update and perspectives]. / Marqueurs du stade neurologique de la trypanosomose humaine africaine: actualités et perspectives.
Med Trop (Mars)
; 68(1): 17-23, 2008 Feb.
Article
em Fr
| MEDLINE
| ID: mdl-18478764
ABSTRACT
Sleeping sickness or human African trypanosomiasis (HAT) is due to parasite infection by a sanguicolous flagellate protozoan of the Trypanosoma brucei genus. The disease is classically divided into two stages, i.e., the hemolymphatic stage and the CNS stage. Disease staging is currently a major challenge for therapeutic decision-making. In the field, diagnosis is based solely on white blood cell (WBC) count and detection of the parasite in the patient's cerebrospinal fluid (CSF). This technique is unreliable and invasive. Numerous studies are now under way to adapt staging to field conditions and to develop a reliable, low-cost, non-invasive test. This article describes the mechanisms underlying CNS involvement during HAT and reviews the different techniques now being studied to simplify and improve diagnosis of the CNS stage.
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Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
/
3_ND
/
4_TD
Base de dados:
MEDLINE
Assunto principal:
Trypanosoma brucei gambiense
/
Tripanossomíase Africana
/
Infecções Protozoárias do Sistema Nervoso Central
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
Fr
Revista:
Med Trop (Mars)
Ano de publicação:
2008
Tipo de documento:
Article