Two newly identified genetic determinants of pigmentation in Europeans.
Nat Genet
; 40(7): 835-7, 2008 Jul.
Article
em En
| MEDLINE
| ID: mdl-18488028
ABSTRACT
We present results from a genome-wide association study for variants associated with human pigmentation characteristics among 5,130 Icelanders, with follow-up analyses in 2,116 Icelanders and 1,214 Dutch individuals. Two coding variants in TPCN2 are associated with hair color, and a variant at the ASIP locus shows strong association with skin sensitivity to sun, freckling and red hair, phenotypic characteristics similar to those affected by well-known mutations in MC1R.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pigmentação
/
Canais de Cálcio
/
Polimorfismo de Nucleotídeo Único
/
Proteína Agouti Sinalizadora
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Humans
País/Região como assunto:
Europa
Idioma:
En
Revista:
Nat Genet
Ano de publicação:
2008
Tipo de documento:
Article