Effect of recombinant TRAIL in a murine co-culture system of osteoclastogenesis.
Eur J Histochem
; 52(1): 75-8, 2008.
Article
em En
| MEDLINE
| ID: mdl-18502726
ABSTRACT
Although some experimental evidence has implicated the TRAIL/TRAIL-receptor system in the regulation of osteoclastogenesis, the only available studies performed so far have been performed on isolated pre-osteoclasts, induced to differentiate by the addition of recombinant RANKL and M-CSF. Using a more physiological co-culture system in the absence of exogenous cytokines, we have here demonstrated that recombinant TRAIL inhibits osteoclast formation, but only at relatively high concentrations (500 ng/mL).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteoclastos
/
Fator Estimulador de Colônias de Macrófagos
/
Ligante RANK
/
Ligante Indutor de Apoptose Relacionado a TNF
/
Osteoprotegerina
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Eur J Histochem
Ano de publicação:
2008
Tipo de documento:
Article