Highly enantioselective organocatalytic conjugate addition of nitromethane to benzylidene acetones.
Chirality
; 20(10): 1120-6, 2008 Nov.
Article
em En
| MEDLINE
| ID: mdl-18506836
ABSTRACT
Six active 4-aryl-5-nitro-pentan-2-ones were synthesized enantioselectively from the corresponding 5-aryl-butenones by asymmetric Michael addition of nitromethane using an imidazolidine-type enantioselective organocatalyst. The ee ratio of the products were between 67 and 100%, determined by HPLC with Chiracel OD. Molecular and crystal structure of 3,4-methylenedioxy-phenyl-5-nitro-pentan-2-one has been studied by single crystal X-ray diffraction.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Butanonas
/
Metano
/
Nitroparafinas
Idioma:
En
Revista:
Chirality
Ano de publicação:
2008
Tipo de documento:
Article