One-pot synthesis of functionalized piperid-4-ones: a four-component condensation.
Org Lett
; 10(13): 2877-80, 2008 Jul 03.
Article
em En
| MEDLINE
| ID: mdl-18533668
The one-pot synthesis of highly substituted piperid-4-ones has been achieved. Diketene is added to a tosyl imine in the presence of TiCl(4) and MeOH, followed by 1 equiv of aldehyde to generate 2,6-disubstituted nonsymmetrical piperid-4-ones as a mixture of cis-/trans-diastereomers in good yields. This mixture of diastereomers can be converted to a single 2,6- cis-diastereomer by epimerization with K(2)CO(3).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperidonas
Idioma:
En
Revista:
Org Lett
Ano de publicação:
2008
Tipo de documento:
Article