Synthesis of glycose carbamides and evaluation of the induction of erythroid differentiation of human erythroleukemic K562 cells.
Eur J Med Chem
; 44(2): 745-54, 2009 Feb.
Article
em En
| MEDLINE
| ID: mdl-18571290
ABSTRACT
A series of carbamides derived from 1,25,6-di-O-isopropylidene-D-gluco- and D-allofuranose as well as their 5,6-O-deprotected analogues (2 and 4) and methyl 3,4-O-isopropylidene-alpha- and beta-D-galactopyranosides (5 and 6) have been prepared in order to evaluate their ability to induce erythroid differentiation of human erythroleukemic K562 cells. Twenty out of 51 carbamides tested exhibit an appreciable activity as inducers of erythroid differentiation and have been fully characterized and described.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ureia
/
Leucemia Eritroblástica Aguda
/
Diferenciação Celular
/
Monossacarídeos
Limite:
Humans
Idioma:
En
Revista:
Eur J Med Chem
Ano de publicação:
2009
Tipo de documento:
Article