Visualizing and quantifying adhesive signals.
Curr Opin Cell Biol
; 20(5): 541-50, 2008 Oct.
Article
em En
| MEDLINE
| ID: mdl-18586481
ABSTRACT
Understanding the structural adaptation and signaling of adhesion sites in response to mechanical stimuli requires in situ characterization of the dynamic activation of a large number of adhesion components. Here, we review high-resolution live cell imaging approaches to measure forces, assembly, and interaction of adhesion components, and the activation of adhesion-mediated signals. We conclude by outlining computational multiplexing as a framework for the integration of these data into comprehensive models of adhesion signaling pathways.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Análise Espectral
/
Técnicas Biossensoriais
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Moléculas de Adesão Celular
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Adesão Celular
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Mecanotransdução Celular
/
Microscopia de Fluorescência
Limite:
Animals
Idioma:
En
Revista:
Curr Opin Cell Biol
Ano de publicação:
2008
Tipo de documento:
Article