Discovery of piperidine carboxamide TRPV1 antagonists.
Bioorg Med Chem Lett
; 18(16): 4569-72, 2008 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-18662879
ABSTRACT
A series of piperidine carboxamides were developed as potent antagonists of the transient receptor potential vanilloid-1 (TRPV1), an emerging target for the treatment of pain. A focused library of polar head groups led to the identification of a benzoxazinone amide that afforded good potency in cell-based assays. Synthesis and a QSAR model will be presented.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperidinas
/
Benzoxazinas
/
Canais de Cátion TRPV
/
Amidas
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Ano de publicação:
2008
Tipo de documento:
Article