Potent and selective pyrazole-based inhibitors of B-Raf kinase.
Bioorg Med Chem Lett
; 18(16): 4692-5, 2008 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-18676143
ABSTRACT
Herein we describe a novel pyrazole-based class of ATP competitive B-Raf inhibitors. These inhibitors exhibit both excellent cellular potency and striking B-Raf selectivity. A subset of these inhibitors has demonstrated the ability to inhibit downstream ERK phosphorylation in LOX tumors from mouse xenograft studies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirazóis
/
Química Farmacêutica
/
Quinases raf
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Proteínas Proto-Oncogênicas B-raf
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Inibidores de Proteínas Quinases
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Ano de publicação:
2008
Tipo de documento:
Article