Integrating expression data with domain interaction networks.
Bioinformatics
; 24(21): 2546-8, 2008 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-18710874
ABSTRACT
UNLABELLED Recent studies have revealed that alternative splicing plays an important role in the observed protein and interaction diversity. Special microarrays allow for measuring gene expression at the exon level and thus for studying alternative transcripts and their corresponding protein domain architecture. We have developed the Cytoscape plugin DomainGraph that enables the visualization and detailed study of domain-domain interactions forming protein interaction networks. In addition, the integration of exon expression data supports the analysis of alternative splicing events and the characterization of their effects on the protein and domain interaction network. Different expression patterns between human tissues or cells can be identified by comparing the generated domain graphs. AVAILABILITY:
The plugin DomainGraph and the online documentation are available at http//domaingraph.bioinf.mpi-inf.mpg.de.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Software
/
Processamento Alternativo
/
Mapeamento de Interação de Proteínas
/
Domínios e Motivos de Interação entre Proteínas
Limite:
Humans
Idioma:
En
Revista:
Bioinformatics
Ano de publicação:
2008
Tipo de documento:
Article