Salicylanilides: selective inhibitors of interleukin-12p40 production.
Bioorg Med Chem
; 16(18): 8760-4, 2008 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-18715785
ABSTRACT
Interleukin (IL)-12p40, a subunit component of both IL-12 and IL-23, is being widely studied for its role in inflammatory disease. As part of an effort to profile cellular signaling pathways across different cell types, we report salicylanilide inhibitors of IL-12p40 production in stimulated dendritic cells. Based on a hypothesis that a desirable therapeutic profile is one that could block IL-12p40 but not IL-6 production, we engaged in directed analoging. This resulted in salicylanilides with similar IL-12p40 related potency but enhanced selectivity relative to IL-6 production.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Salicilanilidas
/
Transdução de Sinais
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Membrana Celular
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Subunidade p40 da Interleucina-12
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Anti-Inflamatórios
Limite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem
Ano de publicação:
2008
Tipo de documento:
Article