Regulation of secretory vesicle traffic by Rab small GTPases.
Cell Mol Life Sci
; 65(18): 2801-13, 2008 Sep.
Article
em En
| MEDLINE
| ID: mdl-18726178
ABSTRACT
Secretion is a fundamental biological activity of all eukaryotic cells by which they release certain substances in the extracellular space. It is considered a specialized mode of membrane trafficking that is achieved by docking and fusion of secretory vesicles to the plasma membrane (i.e., exocytosis). Secretory vesicle traffic is thought to be regulated by a family of Rab small GTPases, which are regulators of membrane traffic that are common to all eukaryotic cells. Classically, mammalian Rab3 subfamily members were thought to be critical regulators of secretory vesicle exocytosis in neurons and endocrine cells, but recent genetic and proteomic studies indicate that Rab3 is not the sole Rab isoform that regulates secretory vesicle traffic. Rather, additional Rab isoforms, especially Rab27 subfamily members, are required for this process. In this article I review the current literature on the function of Rab isoforms and their effectors in regulated secretory vesicle traffic.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas rab de Ligação ao GTP
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Vesículas Secretórias
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Exocitose
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Isoenzimas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cell Mol Life Sci
Ano de publicação:
2008
Tipo de documento:
Article