5alpha-Androst-3-en-17-one oxime.
Acta Crystallogr C
; 64(Pt 9): o508-10, 2008 Sep.
Article
em En
| MEDLINE
| ID: mdl-18758022
ABSTRACT
The title compound, C(19)H(29)NO, is a C17-oxime derivative of a potent aromatase inhibitor, which surprisingly has been found to have no inhibitory power. It crystallizes with two independent molecules in the asymmetric unit. C=N-O-H...N hydrogen bonds link pairs of molecules to form dimers almost parallel to the bc plane. Cohesion of the structure is also due to another three C-H...O hydrogen bonds directed along the a axis. This hydrogen-bonding scheme can be correlated to the almost complete loss of inhibitory power of the title compound.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oximas
/
Inibidores da Aromatase
/
17-Cetosteroides
Idioma:
En
Revista:
Acta Crystallogr C
Ano de publicação:
2008
Tipo de documento:
Article