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The enhancement effect of three sugar alcohols on the fungicidal effect of benzethonium chloride toward Candida albicans.
Ichikawa, T; Yano, Y; Fujita, Y; Kashiwabara, T; Nagao, K.
Afiliação
  • Ichikawa T; Department of Oral & Maxillofacial Prosthodontics and Implantology, The University of Tokushima, Institute of Health Biosciences, 3-18-15 Kuramoto, Tokushima 770-8504, Japan. ichi@dent.tokushima-u.ac.jp
J Dent ; 36(11): 965-8, 2008 Nov.
Article em En | MEDLINE | ID: mdl-18778883
OBJECTIVE: The purpose of this study was to evaluate if the sugar alcohols erythritol, xylitol and sorbitol enhance the fungicidal effect of benzethonium chloride (BTC) toward in vitro candidal biofilms. METHODS: An in vitroCandida albicans biofilm was formed on a plastic coverslip coated with type I collagen. The enhancement of the fungicidal effect was evaluated using microbial assay after treating the biofilm with the test solutions (sugar alcohols: erythritol, xylitol, and sorbitol, each containing BTC solution). RESULTS: No fungicidal effect was observed with sugar alcohols without BTC. The fungicidal effect of erythritol-containing BTC increased with the erythritol concentration. Further, the level of enhancement of erythritol was the highest in three sugar alcohols. CONCLUSION: Sugar alcohols, especially erythritol, enhanced the fungicidal effect of BTC toward in vitro candidal biofilms.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Álcoois Açúcares / Benzetônio / Candida albicans / Biofilmes / Antifúngicos Idioma: En Revista: J Dent Ano de publicação: 2008 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Álcoois Açúcares / Benzetônio / Candida albicans / Biofilmes / Antifúngicos Idioma: En Revista: J Dent Ano de publicação: 2008 Tipo de documento: Article