Iloprost and pentoxifylline attenuate ischemia-reperfusion injury in skeletal muscle in rabbit model.
Ulus Travma Acil Cerrahi Derg
; 14(3): 182-7, 2008 Jul.
Article
em En
| MEDLINE
| ID: mdl-18781412
ABSTRACT
BACKGROUND:
We investigated the effects of iloprost and pentoxifylline on skeletal muscle ischemia-reperfusion injury in a rabbit model.METHODS:
Forty New Zealand white rabbits were grouped into four. In Group 1, iloprost was continuously infused starting half an hour before the reperfusion following a 2-hour ischemia formed by abdominal aortic occlusion, and it was continued during the 4-hour reperfusion period. Group 2 was treated with pentoxifylline, and Group 3 received saline solution. Group 4 was the sham group. Malondialdehyde levels and edema scores in gastrocnemius muscle were evaluated.RESULTS:
Edema score was significantly lower in Group 1 when compared with the control group (Group 1 vs Group 3, p=0.040; Group 2 vs Group 3, p=0.145; Group 1 vs Group 2, p=0.580). Malondialdehyde levels of the medicated groups were significantly lower when compared with the control group (Group 1 60+/-11 nmol/g tissue, Group 2 74+/-11 nmol/g tissue, Group 3 95+/-10 nmol/g tissue; Group 1 vs Group 2, p=0.010; Group 1 vs Group 3, p<0.001; Group 2 vs Group 3, p<0.001; Group 1 vs Group 4, p<0.001; Group 2 vs Group 4, p<0.001; Group 3 vs Group 4 p<0.001).CONCLUSION:
Acute skeletal muscle ischemia is a common problem. We are of the opinion that in the early phase of skeletal muscle ischemia, iloprost and pentoxifylline medication may reduce ischemia-reperfusion injury.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pentoxifilina
/
Vasodilatadores
/
Inibidores da Agregação Plaquetária
/
Traumatismo por Reperfusão
/
Iloprosta
/
Músculo Esquelético
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Ulus Travma Acil Cerrahi Derg
Ano de publicação:
2008
Tipo de documento:
Article