Capsaicin affects aggressive behavior, but not hot plate responding, of adult male mice.
Physiol Behav
; 49(4): 715-9, 1991 Apr.
Article
em En
| MEDLINE
| ID: mdl-1881975
ABSTRACT
Adult male mice of albino Swiss-derived CD-1 strain were used to assess the effects of capsaicin (a powerful agent that produces a marked depletion of the undecapeptide substance P) on both intraspecific aggressive behavior (induced by 8 weeks of individual housing) and pain sensitivity. Capsaicin was given SC, 48 h before behavioral testing. Aggressive behavior, scored during a 5-min session under red light, was significantly enhanced by capsaicin treatment (50 or 100 microliters of a 7.5 mg/ml solution). In fact, Total Aggressive Episodes, Attacks, and Upright Offensive Posture were significantly higher in the two capsaicin-treated groups, while Latency to the first Attack was decreased, when compared to both vehicle or unhandled controls. A concomitant decrease in Submissive Postures and Flee was also evident in capsaicin mice. Hot plate testing (55 +/- 0.1 degrees C, cutoff time 30 s), carried out on nonisolated mice, did not reveal any difference among the two capsaicin groups (same doses) and vehicle or unhandled controls.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nível de Alerta
/
Aprendizagem da Esquiva
/
Nociceptores
/
Capsaicina
/
Agressão
/
Medo
Limite:
Animals
Idioma:
En
Revista:
Physiol Behav
Ano de publicação:
1991
Tipo de documento:
Article