Dermal absorption of environmental contaminants from soil and sediment: a critical review.
J Expo Sci Environ Epidemiol
; 19(2): 119-48, 2009 Feb.
Article
em En
| MEDLINE
| ID: mdl-18830234
ABSTRACT
Risk assessment of hazardous wastes sites may require characterization of the dermal availability of chemical contaminants in soil and/or sediment. Current U.S. Environmental Protection Agency guidance for assessment of dermal exposures to contaminants in water and soil was finalized in 2004 as a supplement (Part E) to the Risk Assessment Guidance for Superfund (RAGS). The soil protocol presented in RAGS Part E is less sophisticated than the water protocol and is supported by less empirical data. Investigations of dermal absorption of soil and sediment-borne contaminants that have been conducted to date include in vitro and in vivo experiments using both human and surrogate skin. A review of that literature was conducted with attention to relevant criteria including consideration of layering effects, degree of chemical saturation of soil, appropriateness of particle size distribution employed, soil-chemical contact time, and continuity of soil-skin contact (in in vivo studies). Most studies published to date are deficient by virtue of execution or reporting on one or more of the selected criteria. In addition the lack of methodological standardization evident in the literature hinders systematic evaluation of results. Since additional experimental work is needed, general agreement on acceptable approaches would be useful. Recommendations for good practice are presented.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Absorção Cutânea
/
Poluentes do Solo
/
Resíduos Perigosos
/
Monitoramento Ambiental
/
Sedimentos Geológicos
Tipo de estudo:
Etiology_studies
/
Guideline
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Expo Sci Environ Epidemiol
Ano de publicação:
2009
Tipo de documento:
Article