Protective effect of a fermented substance from Saccharomyces cerevisiae on liver injury in mice caused by acetaminophen.
Biosci Biotechnol Biochem
; 72(10): 2514-20, 2008 Oct.
Article
em En
| MEDLINE
| ID: mdl-18838823
ABSTRACT
The protective effect of a fermented substance from Saccharomyces cerevisiae (FSSC) on liver injury caused by acetaminophen (AAP) was studied in mice. Mice were pretreated with FSSC (0.5-2.0 g/kg, p.o.) for 4 d, and on the fourth day, the mice received an overdose of AAP (500 mg/kg, i.p.). Subsequently, they were sacrificed at 7 h, and blood was drawn from the abdominal vein and liver samples were collected. Histological and biochemical examinations revealed that the administration of AAP caused liver injury in the mice, including increases in plasma alanine aminotransferase and asparate aminotransferase activities and decreases in the hepatic reduced form of glutathione (GSH) content and antioxidant enzyme activities. Prior to AAP treatment, the mice pretreated with FSSC showed significantly reduced levels of alanine aminotransferase (ALT) and aspirate aminotransferase (AST) activity. Liver histology in the FSSC-pretreated mice was significant. In these mice, pretreatment with FSSC also served to reduce hepatic GSH depletion and the inhibition of antioxidant enzyme activity caused by AAP overdose. In conclusion, oral administration of FSSC significantly reduced AAP-induced hepatic injury in the mice.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saccharomyces cerevisiae
/
Doença Hepática Induzida por Substâncias e Drogas
/
Fermentação
/
Fígado
/
Hepatopatias
/
Acetaminofen
Limite:
Animals
Idioma:
En
Revista:
Biosci Biotechnol Biochem
Ano de publicação:
2008
Tipo de documento:
Article